News & Events


      • Global TILs Machine Learning Annotation Project
      • Worldwide External QUality Control Program on TILs/PDL1


Upcoming and Past Events:

      • Tuesday 30th November, 1:00 PM ESTMohamed Amgad, a member of the TILs-WG, will be giving a Ph.D. defense titled: "Computational discovery of interpretable histopathologic prognostic biomarkers in invasive carcinomas of the breast".

         The talk describes workflows and algorithms for TILs data collection, automated detection, and prognostic modeling.  Read the abstract and Join the meeting 

      • Click here to access the webinar "High-resolution mapping of cells and tissue structures provides a foundation for computational TILs assessment", presented by Mohamed Amgad, member of the TILs Working Group. Mohamed gave a public talk at the Food and Drug Administration (FDA) describing their newest network, NuCLs, and the public release of 220,000 annotations of cell nuclei in breast cancer. 


      • Click here to access the Webinar on High-throughput Truthing-project: a collaboration with FDA, the TILs-WG and the Alliance for Digital Pathology on ML-applications for assessment of TILs.
      • Picture 5th International Immuno-Oncology Biomarker Working Group, SABC2018

Catch up on our latest mailings:

Recent publications and other news:

      • 19th May, 2020 - The Center for Computational Imaging & Personalized Diagnostics at Case Western Reserve University recently published a paper on the relationship between TILs and Epithelial Ovarian Cancer (EOC). Read it here!
      • 12th May, 2020 - TRIPLE WHAMMY! Months of joint effort and global collaborations come together today with the simultaneous publishing of not one, not two, but THREE papers by the TIL Working Group on Nature Partner Journals Breast Cancer
      • Along the development of a Machine Learning Project on TIL-assessment on Breast Cancer HE-slides, the TIL-WG is partnering with PathPresenter. The Faculty of PathPresenter can deliver stunning visual interactive learning experiences in person or online and can connect with other pathologists worldwide (currently 125,000+ users). The freely available 30,000+ slides on the platform make it easy to start today without about having own slides or scanners. Visual information can be found here.
        In our project, the PathPresenter platform allows us to store, organize, and view digitized histopathology whole-slide images as well as create collaborative project workflows to manually annotate regions of interest. We are using PathPresenter to combine the effort of several pathologists, engineers, medical students, etc… to create a dataset of manually annotated tissue types and of lymphocytes in whole-slide images of breast cancer tissue samples. The workflow includes a definition of regions of interest, manual annotation of tumour-associated stroma and stromal tumour-infiltrating lymphocytes (sTILs) within those regions. Furthermore, the bulk of breast tumour is also annotated over the entire whole-slide image. Annotations tools available in PathPresenter, as well as features for sharing and interacting with annotations are of vital importance to provide a large amount of high-quality manual annotations, which are required to train modern machine learning tools such as deep neural networks.
        For more details, please contact Roberto Salgado and/or Rajendra Singh -
      • July 7, 2018 - Our review "Scoring of tumor-infiltrating lymphocytes: From visual estimation to machine learning" is out! From classical image segmentation to machine learning-based approaches including explainable machine learning that allows for quantification and plausibility checks in biomedical research and diagnostics