News & Events

COMING SOON!!

• • • Global TILs Machine Learning Annotation Project
    • Worldwide External QUality Control Program on TILs/PDL1

       

Upcoming and Past Events:

• • • Tuesday 30th November, 1:00 PM EST: Mohamed Amgad, a member of the TILs-WG, will be giving a Ph.D. defense titled: "Computational discovery of interpretable histopathologic prognostic biomarkers in invasive carcinomas of the breast".

       The talk describes workflows and algorithms for TILs data collection, automated detection, and prognostic modeling.  Read the abstract and Join the meeting 

    • Click here to access the webinar "High-resolution mapping of cells and tissue structures provides a foundation for computational TILs assessment", presented by Mohamed Amgad, member of the TILs Working Group. Mohamed gave a public talk at the Food and Drug Administration (FDA) describing their newest network, NuCLs, and the public release of 220,000 annotations of cell nuclei in breast cancer. 

       

    • Click here to access the Webinar on “High-throughput Truthing-project: a collaboration with FDA, the TILs-WG and the Alliance for Digital Pathology on ML-applications for assessment of TILs.”
    • Picture 5^th International Immuno-Oncology Biomarker Working Group, SABC2018

Catch up on our latest mailings:

• • • 18th July 2022 - TILs: is Godot finally arriving?
    • 22nd December 2021 - Hey You! Call me TILS!
    • 19th July 2021 - The TILs and Your Dentist 
    • 19th April 2021 - The Strangeness of Easter and the TILs
    • 24th February 2021 - Join our TILs dance: Listen Baby, there ain't no mountain high enough for the TILs
    • 11th January 2021 -Happy New Year! Read the first communication for 2021: The TILs and the Laughing Anvil
    • 2nd December 2020 - We are ready to leave 2020 behind, read an Update on ongoing TIL projects and why TILs are not such a big deal
    • 29th October 2020 - TILs and Machine Learning: FDA, The Alliance and TILs WG Collaboration
    • 7 September 2020 - Our WG and the need to put our feet in the right place
    • 8th July 2020 - The Science on TILs and the Quest for Meaning in eight items
    • 1st April 2020-  Our Working Group, COVID19 and The Common Good

Recent publications and other news:

• • • 19th May, 2020 - The Center for Computational Imaging & Personalized Diagnostics at Case Western Reserve University recently published a paper on the relationship between TILs and Epithelial Ovarian Cancer (EOC). Read it here!
    • 12th May, 2020 - TRIPLE WHAMMY! Months of joint effort and global collaborations come together today with the simultaneous publishing of not one, not two, but THREE papers by the TIL Working Group on Nature Partner Journals Breast Cancer
      • Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer
      • Report on computational assessment of Tumor Infiltrating Lymphocytes from the International Immuno-Oncology Biomarker Working Group
      • Application of a risk-management framework for integration of stromal tumor-infiltrating lymphocytes in clinical trials
    • Along the development of a Machine Learning Project on TIL-assessment on Breast Cancer HE-slides, the TIL-WG is partnering with PathPresenter. The Faculty of PathPresenter can deliver stunning visual interactive learning experiences in person or online and can connect with other pathologists worldwide (currently 125,000+ users). The freely available 30,000+ slides on the platform make it easy to start today without about having own slides or scanners. Visual information can be found here.
      In our project, the PathPresenter platform allows us to store, organize, and view digitized histopathology whole-slide images as well as create collaborative project workflows to manually annotate regions of interest. We are using PathPresenter to combine the effort of several pathologists, engineers, medical students, etc… to create a dataset of manually annotated tissue types and of lymphocytes in whole-slide images of breast cancer tissue samples. The workflow includes a definition of regions of interest, manual annotation of tumour-associated stroma and stromal tumour-infiltrating lymphocytes (sTILs) within those regions. Furthermore, the bulk of breast tumour is also annotated over the entire whole-slide image. Annotations tools available in PathPresenter, as well as features for sharing and interacting with annotations are of vital importance to provide a large amount of high-quality manual annotations, which are required to train modern machine learning tools such as deep neural networks.
      For more details, please contact Roberto Salgado -roberto@salgado.be- and/or Rajendra Singh - skinpathology@gmail.com
    • July 7, 2018 - Our review "Scoring of tumor-infiltrating lymphocytes: From visual estimation to machine learning" is out! From classical image segmentation to machine learning-based approaches including explainable machine learning that allows for quantification and plausibility checks in biomedical research and diagnostics